Mount Sinai Health System

The Precision Immunology Institute Seminar Series -- Matthew F. Krummel, Ph.D.

Professor, Department of Pathology, UCSF
Robert E. Smith Endowed Chair in Experimental Pathology, UCSF

Important discoveries come from fundamental research and 'How does this work' questions. For the past 15 years, I have studied mechanisms that regulate T cell responses and therefore regulate immune function, using cutting-edge real-time imaging methods to ask these kinds of questions. As a graduate student, I developed expertise in the generation and use of monoclonal antibodies targeted to costimulatory and inhibitory molecules on T cells. One of these projects developed antibodies to CTLA-4, which not only identified an inhibitory pathway of T cell regulation but also could be used to trigger or block that pathway. I subsequently applied these antibodies toward upregulating T cell responses to antigens in vivo and then toward augmenting immune responses to tumors. That approach led to the development of human antibodies of the same type, a therapy now named ipilimumab, and progressing toward FDA approval for treatment of melanoma and other cancers. I am firmly convinced that there is considerably more to be done with respect to modulating signaling in tumor microenvironments.

Tuesday, January 28 at 2:00pm to 3:00pm

Hess Center for Science and Medicine, 2nd Floor, Seminar Room A 1470 Madison Avenue New York, NY 10029