Speaker: Eva Tanner, PhD, MPH
Title: Mixtures of Suspected Endocrine Disrupting Chemicals & Maternal Thyroid Function During Early Pregnancy
Short Bio: Eva is a postdoctoral fellow in the Department of Environmental Medicine and Public Health. She earned an MPH and PhD in Occupational and Environmental Health from the University at Albany. Her research combines methods from epidemiology, machine learning, and risk assessment to evaluate the determinants and health effects of environmental exposures.
Abstract: During early pregnancy the fetus is dependent on maternal thyroid hormones for normal growth and development. Even sub-clinical thyroid hormone changes during this critical period can elicit adverse pregnancy and child health outcomes. Individually, numerous suspected endocrine disrupting chemicals (EDCs) have been linked to altered thyroid hormone levels, but little is known about the combined effect of multiple EDCs. We present preliminary findings for a cross-sectional mixtures analysis between 26 EDCs and maternal thyroid hormone levels during the first trimester of pregnancy among nearly 2000 women from the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study.
Speaker: Miao Yu, PhD
Title: Reactomics: Using mass spectrometry as a chemical reaction detector
Short Bio: Miao Yu is a Postdoctoral Fellow a Postdoctoral Fellow from the Senator Frank R. Lautenberg Environmental Health Sciences Laboratory. He received PhD in environmental science in 2016 from Chinese Academy of Sciences, China. After a postdoctoral training in analytical chemistry from University of Waterloo, Canada, Miao joined Mount Sinai. Miao’s training covered both dry and wet lab skills and his research interests are environmental analytical chemistry and mass spectrometry data analysis. Miao developed R packages(3 on CRAN) for environmental untargeted analysis and metabolomics workflow. Miao has published 29 peer reviewed papers with 2 cover paper (ES&T letter and Analytical Chemistry) and 1 annual best paper from ES&T letter(2018), 1 book chapter and 3 Chinese patents. He has organized two workshops for metabolomics data analysis at University of Waterloo and University of California, Irvine.
Abstract: Chemical reactions among small molecules enable untargeted metabolomics analysis, in which small molecules within samples are identified through high-throughput assays. In standard mass spectrometry-based metabolomics, first significant small molecules are identified, then their biochemical relationships are probed to reveal biological fate (environmental studies) or biological impact (physiological response). However, we propose that biochemical relationships could be directly retrieved through untargeted high-resolution paired mass distance (PMD), which investigates chemical pairs in the samples without a priori knowledge of the identities of those participating compounds. We present the potential for this chemical reaction detector, or ‘reactomics’ approach, linking PMD from the mass spectrometer to biochemical reactions obtained via data mining of known small molecular metabolites/compounds and reaction databases. This approach encompasses both quantitative and qualitative analysis of reaction by mass spectrometry, and its potential applications include PMD network analysis, source appointment of unknown compounds, and biomarker reaction discovery instead of compound discovery. Such applications may promote novel biological discoveries that are not currently possible with classical chemical analysis.
Date: Thursday, January 30th, 2020
Time: 12PM - 1PM
Location: CAM Building, 17 East 102nd Street - West Tower Elevator, 5th Floor, D5-122
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*Light lunch will be provided. We are trying to be more eco-friendly, so please bring your own reusable cup or water bottle.
Thursday, January 30 at 12:00pm to 1:00pm
CAM Building, 17 E 102nd St - West Tower Elevator, 5th Floor, D5-122, D5-122