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X-WR-CALNAME:Rising Star in Genomic Health Virtual Seminar - Na Cai\, DPhil
  - "Learning Lifetime Disease Liability Reveals and Removes Genetic Confou
 nding in Electronic Health Records"
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260715T072512Z
UID:tag:localist.com\,2008:EventInstance_52675160949183
DTSTART:20260512T130000Z
DTEND:20260512T140000Z
DESCRIPTION:"Learning Lifetime Disease Liability Reveals and Removes Geneti
 c Confounding in Electronic Health Records"\n\n \n\nAbstract:\n\nElectroni
 c health records (EHRs) have become the cornerstone of population-scale ge
 netic studies\, but factors including patterns of healthcare use shape whi
 ch and how diagnoses are recorded\, leading to confounding effects in gene
 tic associations with EHR codes.  In this study we propose EDGAR\, a deep 
 learning framework that recovers lifetime disease liability from EHR by al
 igning diagnostic codes with clinically validated measures and disease lab
 els in a set of individuals prioritized through active learning. EDGAR yie
 lds representations that better capture disease-specific effects in genome
 -wide association analyses (GWAS). It also enables us to isolate a genetic
  factor that captures systemic biases in EHR codes\, which distorts cross-
 disease correlations and drives spurious links with behavioral and socio-e
 conomic traits. We find that this factor generalizes across EHRs\, and its
  identification in one EHR enables its removal from existing GWAS in anoth
 er. Overall\, our work presents a promising direction for improving specif
 icity of EHR-based GWAS.\n\nDate: Tuesday\, May 12\, 2026\nTime: 9 - 10am 
 ET\nZoom Registration Link\nZoom Meeting ID: 961 8387 9377\n\nZoom meeting
  info will be sent after registration.\n \n\n\n\n \n\nSpeaker:\n\n \n\nNa 
 Cai\, DPhil\nAssistant Professor\nDepartment of Biosystems Science and Eng
 ineering\nBasel Research Centre for Child Health\nna.cai@bsse.ethz.ch\nX: 
 @caina89\nBlueSky: @caina89.bsky.social\n\n\nDr Na Cai is a statistical ge
 neticist whose research focus is primarily on the genetic underpinnings of
  psychiatric disorders. Na has performed the first genetic study that iden
 tified significant and replicated genetic associations with Major Depressi
 ve Disorder during her PhD\, and have since worked on critically assessing
  and maximizing the use of all types of available data (clinical cohorts\,
  volunteer-based biobanks\, self-reports through consumer genomic companie
 s\, and electronic health records) specifically for genetic research. Her 
 goal is to identify the genetic effects that are specific to the (potentia
 lly heterogeneous) pathologic pathways in psychiatric disorders\, and use 
 them to identity genes and cell types that are potentially relevant for de
 velopment of targeted treatments and interventions.\n\n\nFaculty Host\n\nC
 helsea Lowther\, PhD\nAssistant Professor\nInstitute for Genomic Health
LOCATION:
SUMMARY:Rising Star in Genomic Health Virtual Seminar - Na Cai\, DPhil - "L
 earning Lifetime Disease Liability Reveals and Removes Genetic Confounding
  in Electronic Health Records"
URL;VALUE=URI:https://events.mountsinaihealth.org/event/rising-star-in-geno
 mic-health-virtual-seminar-na-cai-dphil-learning-lifetime-disease-liabilit
 y-reveals-and-removes-genetic-confounding-in-electronic-health-records
CATEGORIES:Academic
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