Title: Comprehensive Characterization of the Human Placental Hydroxymethylome
Speaker: Corina Lesseur, MD, PhD, Postdoctoral Fellow, Environmental Medicine and Public Health
Bio: Corina is a Postdoctoral Fellow at the Department of Environmental Medicine and Public Health. She holds an M.D. from the Central University of Venezuela and a Ph.D. in Molecular Epidemiology from Dartmouth College. Prior to arriving at Mount Sinai in 2017, she completed a Genetic Epidemiology Postdoctoral Fellowship at the International Agency for Research on Cancer (IARC). In 2019, Dr. Lesseur was awarded an NICHD Career development (K99) Award to perform Integrative analysis of the human placental epi/genome in relation to fetal growth.
Abstract: The placenta is the crucial regulator of the intrauterine environment that influences maternal and fetal health. The placental epi/genome orchestrates placental function by controlling gene expression. 5-methylcytosine (5mC) DNA methylation is a widely-studied epigenetic mechanism involved in gene expression control. More recently, a novel epigenetic mark has been described; 5-hydroxymethylcytosine (5hmC) which has distinct roles in gene regulation from 5-methylcytosine. However, current knowledge of genome-wide DNA hydroxymethylation distribution and function across tissues, including placenta is limited. In this study, we performed a genome-wide characterization of placental hydroxymethylation integrated with gene expression and genotype data, to construct detailed cross-omic map of 5hmC in term human placenta. Comprehensive studies of 5hmC in normal tissues are paramount to understand the influence of this new epigenetic mark in disease.
Date: Thursday, February 27th, 2020
Location: CAM Building, 17 E 102nd, 5th Floor West, D5-122
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*Light lunch will be provided. We are trying to be more eco-friendly so please bring your own reusable cup or water bottle.
Thursday, February 27 at 12:00pm to 1:00pm
CAM Building, 17 E 102nd St, 5th Floor West, D5-122, D5-122 CAM Building, 17 E 102nd St, 5th Floor West, D5-122