Speaker: Jessie Buckley, PhD, MPH, Assistant Professor
Title: "Gestational perfluoroalkyl substance exposures and childhood bone health: assessing mixtures and mediation"
Bio: Jessie Buckley, PhD, MPH is an Assistant Professor of Environmental Health & Engineering and Epidemiology (joint) at the Johns Hopkins Bloomberg School of Public Health. Her research program aims to characterize environmental exposures during early life and determine their effects on child physical growth and development. As an NIEHS Outstanding New Environmental Scientist (ONES) awardee, she is studying effects of early life environmental chemical exposures on childhood bone health. Dr. Buckley received her MPH in Environmental and Occupational Health from the George Washington University and PhD in Epidemiology from the University of North Carolina at Chapel Hill.
Abstract: Perfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and human tissues including bone. In cross-sectional studies, PFAS have been associated with lower bone mineral density in children and adults. Effects of gestational PFAS exposures on bone health are relatively unstudied despite animal research reporting adverse effects of developmental PFAS exposures on bone density and remodeling. In this seminar, Dr. Buckley will present her work investigating associations of gestational PFAS exposures and their mixtures with bone mineral density among adolescents in the Health Outcomes and Measures of the Environment (HOME) Study. Given the endocrine disrupting and obesogenic effects of PFAS, she will also present findings assessing mediation of associations by pubertal status and lean mass to elucidate potential biological mechanisms.
Thursday, September 17 at 12:00pm to 1:00pm