I-HDS and TCI-BSRF (Biostatistics Shared Resource Facility) invites you to join its Biostatistics Seminar Workshop being held, Thursday, March 14th at 2:00pm in room 8-101 in the Hess (CSM) Building, 8th Floor. Our featured guest will be Li-Xuan Qin, PhD, Assoc. Attending Biostatistician, MSKCC.
Talk Title: "Aligning Data Normalization with Analysis Goals for Reproducible Molecular Prediction."
Data normalization is an important preprocessing step for molecular data that contain unwanted variations due to disparate experimental handling. There has been a critical yet over-looked disconnection between the use of data normalization and the goals of subsequent analysis: on one hand, methods for data normalization that have been developed for group comparison frequently encounter ‘off-label’ use for other analysis goals such as sample classification; on the other hand, analysis are often performed on normalized data neglecting potential normalization ‘side-effects’ such as over-compressed data variability. A bridge between these two is made possible by a unique pair of microRNA datasets on the same set of tumor samples that were collected at Memorial Sloan Kettering Cancer Center. In this talk, Dr. Qin will share her findings from this dataset pair on the role of data normalization for identifying molecular biomarkers that are differentially expressed between sample groups and molecular signatures that can predict sample type, two important quantitative tools that are in dire need to tailor treatment choices for personalized medicine.
Dr. Li-Xuan Qin is Associate Member in Biostatistics at Memorial Sloan Kettering Cancer Center. She received her PhD in biostatistics from the University of Washington in 2005, and joined MSKCC in the same year. Her research focuses on the development of benchmark data, analytic methods, and computational tools for enabling reproducible statistical translations of cancer genomics data. She collaborates with multidisciplinary engaged in research on sarcoma, for design and analysis of retrospective and prospective studies, and serves as co-Director of the Biostatistics and Bioinformatics Core in the Soft Tissue Sarcoma SPORE.
Thursday, March 14 at 2:00pm to 3:00pm
Hess Building, 8-101