I-HDS and TCI-BSRF (Biostatistics Shared Resource Facility) invites you to join its Biostatistics Analysis Workshop being held, Thursday, April, 25th at 2:00pm in room 9-101 in the Hess Building, 9th Floor. Our featured guest will be Behrang Mahjani, PhD, Statistical & Scientific Computing Postdoctoral Fellow, Psychiatry, ISMMS.
Talk Title: "Maternal effects as causes of risk for obsessive-compulsive disorder."
Behrang Mahjani joined the Seaver Autism Center for Research and Treatment, and Division of Tics, OCD, and Related Disorders in September 2017 as a postdoctoral fellow. He was formerly a postdoctoral fellow at the Karolinska Institutet in Sweden. His research is focused on the role of maternal effects in the etiology of pediatric psychiatric disorders, including autism, OCD, and chronic tic disorder. He obtained his PhD in computational statistics from Uppsala University, Sweden, in June of 2016, and previously received MSc in mathematical statistics and MSc in complex adaptive systems from Chalmers University of Technology, Sweden. While at the Seaver Autism Center, he is affiliated with Karolinska Institutet, Department of Medical Epidemiology and Biostatistics.
In a population-based cohort study of 822,843 Swedish individuals born between 1982 and 1990, we observed evidence for significant genetic maternal effects in risk for obsessive-compulsive disorder. Genetic maternal effects are the influences of maternal genetic variation on the phenotype of the offspring, above and beyond influences of transmitted genetic variation.
In this work, we used generalized mixed linear models (GLMM) to estimate the proportion of total variance explained by genetic and environmental factors. GLMM is a flexible and general approach that can handle complex pedigrees of varying size and structures for analyzing maternal effects.
Thursday, April 25 at 2:00pm to 3:00pm
Hess Building, 9-101 1470 Madison Ave