BEGIN:VCALENDAR VERSION:2.0 PRODID:icalendar-ruby CALSCALE:GREGORIAN X-WR-CALNAME:High-throughput Urine Exposomic Studies for Global Health: Ass essing Regional and Sex-Dependent Differences in Cigarette Smoke and Coffe e Co-exposures - Dr. Philip Britz-McKibbin X-WR-TIMEZONE:Eastern Time (US & Canada) BEGIN:VEVENT DTSTAMP:20260614T035910Z UID:tag:localist.com\,2008:EventInstance_52746114789045 DTSTART:20260508T160000Z DTEND:20260508T170000Z DESCRIPTION:Dr. Philip Britz-McKibbin is a Professor at the Department of C hemistry and Chemical Biology at McMaster University in Hamilton\, Canada. Dr. Britz-McKibbin obtained his BSc in Chemistry (U. Toronto\, 1994)\, an d PhD in Analytical Chemistry (UBC\, 2000) and a Japan Society for Promoti on of Science PDF position in Japan (Hyogo University\, 2001-2003) prior t o starting his academic position at McMaster. His research group is an aff iliate member of The Metabolomics Innovation Centre (TMIC) – Canada’s national metabolomics laboratory. His research interests in bio-analytical chemistry\, separation science\, mass spectrometry and metabolomics inclu de the design of novel analytical strategies to quantify and identify meta bolites of clinical significance in biological samples. Philip’s laborat ory aims to discover new biomarkers that support early detection and impro ved therapeutic interventions with emphasis on inherited metabolic disorde rs and chronic human diseases ranging from cystic fibrosis to inflammatory bowel disease. His research interests also include the development of hi gh throughput screening methods for large-scale epidemiological studies wi th recent focus on comprehensive drug surveillance and assessment of dieta ry and tobacco smoke exposures in support of global health.\n\nTitle of Ta lk: High-throughput Urine Exposomic Studies for Global Health: Assessing R egional and Sex-Dependent Differences in Cigarette Smoke and Coffee Co-exp osures \n\nTobacco smoking and coffee consumption are two modifiable lifes tyle factors relevant to global health that are also strongly associated w ith each other. Although moderate coffee consumption alone may confer some health benefits\, its combination with tobacco may paradoxically exacerba te tobacco-related harms. To date\, observational studies have reported co ntradictory findings on the causal link between tobacco smoking and coffee intake when relying on self-reports that are prone to bias since sociocul tural practices and products consumed vary widely between countries. \n\nH erein\, we investigate tobacco smoke and coffee co-exposures in a sub-coho rt of the Prospective Urban Rural Epidemiological (PURE) study (n=5\,000\; 14 countries) using high-throughput multisegment capillary electrophoresi s-mass spectrometry in positive and negative ion modes. A targeted analysi s of the seven urinary nicotine metabolites (i.e.\, total nicotine equival ent) was used to verify tobacco smoke exposures\, whereas nicotine metabol izers were classified based on the nicotine metabolic ratio as an indicato r of their nicotine dependence. Untargeted metabolite analyses was also pe rformed to identify specific urinary biomarkers associated with coffee con sumption distinct from other caffeinated beverages\, including tea and sod a. Untargeted profiling identified population-generalizable coffee biomark ers\, validated for selectivity\, dose-response\, association strength\, a nd precision. A panel of urinary biomarkers of coffee intake generalizable to diverse populations in PURE were then validated based on several crite ria\, including selectivity\, association strength\, dose-response\, and p recision. \n\nFor the first time\, we report striking sex- and regional va riations in active/secondhand smoke exposures across country income groups \, not reliably captured by self-reports in PURE. Further\, fast nicotine- metabolizing female smokers had the highest coffee intake\, exceeding age/ BMI-matched males and non-smoking females\, as confirmed by robust urinary biomarkers of coffee intake. This work may help guide more effective smok ing cessation strategies for chronic disease prevention in high-risk femal e smokers by concomitantly reducing coffee exposures.\n\n \n\n \n\n \n\nTi me: May 08\, 2026 12:00 PM Eastern Time \n\n \n\nPlease register for the z oom using the link below\n\nZOOM Registration Link:\n\n \n\nhttps://mounts inai.zoom.us/j/96290264615 LOCATION: SUMMARY:High-throughput Urine Exposomic Studies for Global Health: Assessin g Regional and Sex-Dependent Differences in Cigarette Smoke and Coffee Co- exposures - Dr. Philip Britz-McKibbin URL;VALUE=URI:https://events.mountsinaihealth.org/event/high-throughput-uri ne-exposomic-studies-for-global-health-assessing-regional-and-sex-dependen t-differences-in-cigarette-smoke-and-coffee-co-exposures-dr-philip-britz-m ckibbin CATEGORIES:Lecture/Seminar END:VEVENT END:VCALENDAR