Mount Sinai Health System

Department of Environmental Medicine & Public Health Grand Rounds

Title:         “HEME Oxygenase One (HO-1) as a Protective Agent in Occupational Lung Diseases”   

Speaker:    Elizabeth Fireman, MD, Head of the Laboratory of Pulmonary and Allergic Diseases and Pulmonology Department, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel 

 Date:           Wednesday, May 16 , 2018 

Time:           12PM - 1PM

Location:    CAM Building, 17 East 102nd Street - West Tower Elevator, 5th Floor, D5-122

 Short Bio:   

 Dr. Fireman, is the  Head of the Laboratory of Pulmonary and Allergic Diseases and Pulmonology Department, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, and past chair of the Department of Occupational and Environmental Health School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. My research is focused on biomonitoring of occupational and environmental lung diseases by noninvasive approaches. I have authored more than 100 peer-reviewed publications with the last having been focused on chronic beryllium diseases and artificial stone-induced silicosis  

Abstract: 

Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the induction of ferritin, an iron-binding protein). HO-1 serves as a ‘protective’ gene by virtue of the anti-inflammatory, anti-apoptotic and anti-proliferative actions of one or more of these three products. The HO-1 promoter consists of repeating sequences of guanine and thymine (GT)n. The number of repetitions higher than 25 in promoter (L) causes a high expression of HO-1 relative to a number of repeats that is lower than 25 (S). The number of repeats (GT)n in the HO-1 promoter in the study population (n=67) ranges from 17 repeats to 32 repeats.

The "beneficial" effect of HO-1 was studied in two occupational lung diseases:

  • Chronic beryllium lung disease
  • Artificial stone-induced silicosis
  •  

  If you need more information please contact:

maud.dupuy@mssm.edu

*Light lunch will be provided

 

 

 

 

Wednesday, May 16 at 12:00pm to 1:00pm

17 E. 102nd Street - 5th Floor - West Elevator - Room D5-122, D5-122 SAME AS ABOVE