Speaker: Lida Chatzi, MD, PhD, Associate Professor, University of Southern California
Title: “Forever Chemicals”: An environmental link to pediatric obesity and metabolic disease
Bio: Dr. Lida Chatzi is Associate Professor of Preventive Medicine at the Keck School of Medicine of USC, Division of Environmental Health. She is a physician-environmental epidemiologist leading an interdisciplinary program of research focused on advancing our understanding of how diet and exposure to environmental chemicals affect metabolic disease, with a particular focus on pregnancy and childhood. She has published widely on the effects of early life exposure to endocrine disrupting chemicals on obesity, type 2 diabetes, and non-alcoholic fatty liver disease. In support of this work, she has led studies examining maternal and infant diet and their associations with the risk of adiposity and asthma in childhood. She is the principal investigator of the “Rhea” pregnancy cohort in Greece and she have catalyzed and led several transatlantic pediatric obesity research initiatives leveraging intellectual resources and cohorts in Europe and the United States. She is the PI in several EU and NIH research grants.
Abstract: Over the past 40 years, obesity has increased rapidly in children and adolescents worldwide, causing a large burden of disease, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). The known persistence of childhood obesity into adulthood increases risk for lifetime morbidity and premature mortality. Convincing evidence suggests that diet and activity level are not the only factors in this trend—chemical “obesogens” may alter human metabolism and predispose some people to gain weight. In the past decade, prospective birth cohorts, including our own studies, have associated prenatal exposures of suspected endocrine-disrupting chemicals (EDCs) with increased risk for obesity. The underlying mechanisms explaining the obesogenic effects of these environmental exposures remain largely unknown. Experimental studies showed that different obesogenic compounds may have different mechanisms of action, some affecting the number of fat and the size of fat cells, and others the hormones that affect appetite, satiety, food preferences, and energy metabolism. Omics technologies are promising tools to shed light on early, preclinical, perturbations of biological pathways in response to environmental exposures and implementation of these technologies has revolutionized obesity research as they can reduce uncertainties in risk assessment and improve strategies for disease prevention. This presentation will give an overview of some of the first human studies to date investigating the impact of environmental mixtures (exposome) on metabolic diseases (obesity, type 2 diabetes, and non-alcoholic fatty liver disease) in children using innovative study designs, including novel measurement approaches and integration of data across various exposures and omics biomarkers.
Date: Thursday, March 19th, 2020
Location: CAM Building, 17 E 102nd, 5th Floor West, D5-122
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*Light lunch will be provided. We are trying to be more eco-friendly so please bring your own reusable cup or water bottle.
Thursday, March 19 at 12:00pm to 1:00pm
CAM Building, 17 E 102nd, 5th Floor West, D5-122, D5-122 17 E 102nd, 5th Floor West, D5-122