Title: Integrative Analysis of Methylation Quantitative Trait Loci (meQTLs) in Human Placenta
Speaker: Corina Lesseur, MD, PhD, Postdoctoral Fellow, Department of Environmental Medicine and Public Health
Bio: Corina Lesseur is a Postdoctoral Fellow in the Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai. She trained as a molecular epidemiologist focused on placental epigenetics in relation to pregnancy outcomes at Dartmouth College. Prior to arriving at Mount Sinai in 2017, she was a Postdoctoral Fellow at the International Agency for Research on Cancer (IARC).
Abstract: Inter-individual variation in DNA methylation has been linked to age, sex, environmental exposures, and inherited genetic variants such as single nucleotide polymorphisms (SNPs). The influence of individual’s genotype on DNA methylation is known as methylation quantitative trait loci (meQTL). Characterizing the relationship between fetal genotypes and epigenetic variation in human placenta could provide mechanistic insight into fetal growth and developmental programming of adult onset diseases. In this study, we performed a genome-wide analysis of placental meQTL loci and integrated these results with gene expression and birth-weight related SNPs (discovered through GWAS) with the aim to provide functional insight into the effects of the intrauterine environment on fetal growth.
Date: Thursday, February 21st 2019
Location: CAM Building, 17 East 102nd Street, West Tower Elevator, 5th Floor, D5-122
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*Light lunch will be provided
Thursday, February 21 at 12:00pm to 1:00pm
CAM Building, 17 East 102nd Street,West Tower Elevator, 5th Floor, D5-122